This exDerimen.t was investigated 5 classes of immunoglobulins to Hantaan virus in patients of hemorrhagic fever with renal syndrome from immediately after onset of the disease to 2 months.
The results obtained from this experiment were as follows:
1. The highest titer of IgG antibody to Hantaan virus could be demonstrated and reached to a peak between 2nd and 3rd weeks from onset of the disease.
Most of the patients showed high titers of immunofluorescent antibody between 4,096 and
16,384.
2. IgA antibody to Hantaan virus in patients of hemorrhagic fever with renal syndrome was relatively high and reached a peak between 2nd and 3rd weeks from onset of the disease, and it was maintained with high titer of antibody for 2 months. Peak titiers of immunofluorescent antibody was between 1, 024 and 4, 096.
3. IgM antibody to Hantaan virus in the patients of hemmorrhagic fever was demonstrated in all of the patients after onset of the disease and the titers of the antibody were between 256 and 4,096, and was also demonstrated until 2 months.
4. Though IgD antibody in patients of hemorrhagic fever with renal syndrom was reached to a peak between 2nd and 3rd weeks after onset of the disease, the titers of the antibody were within 1,024 and it was demonstrated until 2 month.
5. IgE antibody in the patients of hemorrhagic fever was irregularly appeared and could be demonstrated the increase of antibody in half of the patients, but not in the remainder.
Above results revealed that the demonstration of IgM could be the important criteria in diagnosis of the primary infection with Hantaan virus and the significances of increase of IgD antibodies to Hantaan virus during illness remain to be analysed.
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